In the future, the researchers plan to study how the interplay of those types of energy inputs affects the cells.
The researchers' model shows that reorganization of the cytoskeleton could account for such deformation.
Mobility is a key factor in diseases like malaria and the genetic disorder sickle cell anemia, both of which render red blood prix prostituée croatie cells unable to flow through narrow capillaries.Using the new model, researchers can study how the infection affects the blood cells on a molecular level to make them less deformable.To change shape, the cells rearrange protein components of their internal scaffolding, called the cytoskeleton.Proceedings of the National Academy of Sciences, scientists will be able to examine how these disorders affect the cells at the molecular level.The new model could also be used to study several types of blood disorders, including malaria, as the cell membrane and cytoskeleton are altered by the presence of the parasite inside the cell.In this review, we first discuss the biological and physical mechanisms of cell shape control.In patients with sickle cell anemia, red blood cells take on a sickle shape that prevents them from flowing through blood vessels.The research was funded by the National Institutes of Health.Every red blood cell has a cytoskeleton, a sort of scaffolding made of protein molecules called spectrin, attached to the inside of its cell membrane in a brush-like network.With this new discovery, published in the March 22 online edition.The research could help scientists better understand certain blood disorders like malaria and sickle cell anemia.A version of this article appeared.A new study has discovered how exactly the teeny hat-shaped cells deform themselves to fit through these micro-tunnels.
When the bonds within that protein network or between the network and the cell membrane are broken, holes open up in the cytoskeleton, allowing the cell to become more fluidic and squeeze through narrow passages.
"Now we can study how molecular structure affects the shape, which affects the mechanical properties, and both of which affect mobility he said.
Human red blood cells rushing through the body to carry oxygen and carbon dioxide to and from the organs are forced to squeeze through smaller and smaller blood vessels.
Together with cell growth, division and death, changes in cell shape are of central importance for tissue morphogenesis during development.
Cell shape is the product of a cell's material and active properties balanced by external forces.